The chlamydial invasin-like protein gene conundrum
نویسندگان
چکیده
منابع مشابه
A gene for dnaB like protein in chlamydial plasmid.
The dnaB gene of Escherichia coli codes for a protein essential in the initiation and elongation of DNA replication. Chlamydia trachomatis, an obligate intracellular parasite which causes ocular and genital infections in man, has a 7.5kb plasmid (pCTTl). Examination of the complete nucleotide sequence (1) revealed nine open reading frames. The derived amino acid sequence of one of the ORFs (0RF...
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Chlamydial trachomatis is one of the few prokaryotic organisms known to contain proteins that bear amino acid similarity to eukaryotic histone H1. It is also appreciated that chlamydial histone-like proteins, designated Hc1 and Hc2, can bind DNA and are presumably involved in the condensation of infectious elementary bodies. However, there is no information on either the orientation of Hc1 and ...
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Chlamydia trachomatis is one of the few prokaryotic organisms known to contain proteins that bear homology to eukaryotic histone H1. Changes in macromolecular conformation of DNA mediated by the histone H1-like protein (Hc1) appear to regulate stage specific differentiation. We have developed a cross-linking immunoprecipitation protocol to examine in vivo protein-DNA interaction by immune preci...
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A comprehensive TnphoA mutant library was constructed in Yersinia pestis KIM6 to identify surface proteins involved in Y. pestis host cell invasion and bacterial virulence. Insertion site analysis of the library repeatedly identified a 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein (Ilp), similar to the Gram-negative intimin/invasin family of surface proteins. Deletion mutant...
متن کاملFollowing the Footsteps of Chlamydial Gene Regulation
Regulation of gene expression ensures an organism responds to stimuli and undergoes proper development. Although the regulatory networks in bacteria have been investigated in model microorganisms, nearly nothing is known about the evolution and plasticity of these networks in obligate, intracellular bacteria. The phylum Chlamydiae contains a vast array of host-associated microbes, including sev...
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ژورنال
عنوان ژورنال: Microbes and Infection
سال: 2007
ISSN: 1286-4579
DOI: 10.1016/j.micinf.2007.03.006